| 靶标 | Serine/threonine-protein kinase mTOR, EC:2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, EC:2.7.10.2, MTOR |
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| 背景 | Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). 1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 120870987. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 152688628. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 154677189. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 1554562510. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470 |
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