Anti-RNF126 Polyclonal Antibody (HC013014)

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概述
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参考文献
产品说明书

概述

货号

HC013014

品牌

abinScience

描述

Anti-RNF126 Polyclonal Antibody (HC013014) is a rabbit polyclonal antibody detecting RNF126 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant RNF126 (Met1-Ser311).

靶标

E3 ubiquitin-protein ligase RNF126, EC:2.3.2.27, RING finger protein 126, RNF126

内毒素水平

Please contact with the lab for this information.

观测分子量

~40 kDa

纯化方式

Purified by antigen affinity column.

Accession号

Q9BV68, Q91YL2, Q0II22

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

E3 ubiquitin-protein ligase RNF126 is a ~33 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor.

1. Delker, RK. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 1029-34. PMID: 23277564

2. Smith, CJ. et al. (2014) Experimental cell research 320, 219-32. PMID: 24275455

3. Rodrigo-Brenni, MC. et al. (2014) Molecular cell 55, 227-37. PMID: 24981174

4. Liu, W. et al. (2023) Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10, e2203884. PMID: 36563124

5. Mock, JY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 11679-11684. PMID: 29042515

6. Smith, CJ. et al. (2013) Journal of cell science 126, 1366-80. PMID: 23418353

7. Zhi, X. et al. (2013) Cancer research 73, 385-94. PMID: 23026136

Note

For research use only

图片

参考文献

产品说明书

Anti-RNF126 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-RNF126 Polyclonal Antibody (HC013014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-RNF126 Polyclonal Antibody (HC013014)

概述

图片

参考文献

产品说明书

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