Anti-Mouse TIGIT Recombinant Antibody (SAA2311) (MS739013)

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50ug
100ug
1mg

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货号	MS739013
品牌	abinScience
种属反应性	Mouse
应用	WB, in vivo blocking
同种型	IgG2a, kappa
克隆号	SAA2311
经测试应用	WB
靶标	T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3, Tigit, Vstm3
内毒素水平	Please contact with the lab for this information.
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P86176
状态	Liquid
保存溶液	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Note	For research use only
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Western blot

Western blot analysis was performed using anti-TIGIT monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse TIGIT (Catalog No: MS739012)
Lane 2: negative control

产品说明书

Anti-Mouse TIGIT Recombinant Antibody (SAA2311).pdf

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Anti-Mouse TIGIT Recombinant Antibody (SAA2311) (MS739013)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse TIGIT Recombinant Antibody (SAA2311) (MS739013)

概述

图片

参考文献

产品说明书

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