Anti-PMS2 Polyclonal Antibody (HA596014)

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50ug
100ug

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概述
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参考文献
产品说明书

概述

货号

HA596014

品牌

abinScience

描述

Anti-PMS2 Polyclonal Antibody (HA596014) is a rabbit polyclonal antibody detecting Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2; PMS2; PMSL2 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human PMS2 (Asp19-Asn371).

靶标

Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2; PMS2; PMSL2

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P54278, Q13401, Q13670, A4D2B8, P54279, A8MQ11, O95744

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Mismatch repair endonuclease PMS2 is a ~95 kDa protein. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch.

1. D'Arcy, BM. et al. (2019) Human mutation 40, 458-471. PMID: 30653781

2. D'Arcy, BM. et al. (2022) Molecular genetics & genomic medicine 10, e1908. PMID: 35189042

Note

For research use only

图片

参考文献

产品说明书

Anti-PMS2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PMS2 Polyclonal Antibody (HA596014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PMS2 Polyclonal Antibody (HA596014)

概述

图片

参考文献

产品说明书

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