UDP-glucuronosyltransferase 1A1 (UGT1A1) is a ~59 kDa protein. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha). 1. Gagné, JF. et al. (2002) Molecular pharmacology 62, 608-17. PMID: 121814372. Lépine, J. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5222-32. PMID: 154722293. Udomuksorn, W. et al. (2007) Pharmacogenetics and genomics 17, 1017-29. PMID: 180042064. Girard, H. et al. (2007) Pharmacogenetics and genomics 17, 1077-89. PMID: 180042125. Itäaho, K. et al. (2008) Drug metabolism and disposition: the biological fate of chemicals 36, 2307-15. PMID: 187192407. Sneitz, N. et al. (2013) Drug metabolism and disposition: the biological fate of chemicals 41, 582-91. PMID: 232888678. Little, JM. et al. (2004) Journal of lipid research 45, 1694-703. PMID: 152318529. Li, X. et al. (2011) Drug metabolism and pharmacokinetics 26, 341-50. PMID: 21422672 | 
