Anti-PBLD Polyclonal Antibody (HA616014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HA616014

品牌

abinScience

描述

Anti-PBLD Polyclonal Antibody (HA616014) is a rabbit polyclonal antibody detecting Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP in ELISA, IHC, WB. Suitable for Human and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human PBLD (Met1-Ala288).

靶标

Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P30039, Q2HJF4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Phenazine biosynthesis-like domain-containing protein (PBLD) is a ~31 kDa protein. Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signaling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication. Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection.

1. Zhu, H. et al. (2024) Cell death & disease 15, 727. PMID: 39362857

2. Chu, F. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2401174121. PMID: 39589880

3. Hou, P. et al. (2025) Nature communications 16, 496. PMID: 39779683

4. Li, DM. et al. (2013) World journal of gastroenterology 19, 2781-92. PMID: 23687415

Note

For research use only

图片

Western blot

Western blot analysis was performed using anti-PBLD polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate

参考文献

产品说明书

Anti-PBLD Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PBLD Polyclonal Antibody (HA616014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PBLD Polyclonal Antibody (HA616014)

概述

图片

参考文献

产品说明书

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