Anti-ABCD1 Polyclonal Antibody (HA690014)

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50ug
100ug

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概述
图片
参考文献
产品说明书

概述

货号

HA690014

品牌

abinScience

描述

Anti-ABCD1 Polyclonal Antibody (HA690014) is a rabbit polyclonal antibody detecting ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy protein; ALDP; ABCD1; ALD in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human ABCD1 (Leu461-Thr745).

靶标

ATP-binding cassette sub-family D member 1; 3.1.2.-; 7.6.2.-; Adrenoleukodystrophy protein; ALDP; ABCD1; ALD

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P33897, P48410, D3ZHR2

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

ATP-binding cassette sub-family D member 1 (ABCD1) is a ~82 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization.

1. Roerig, P. et al. (2001) FEBS letters 492, 66-72. PMID: 11248239

2. Guimarães, CP. et al. (2005) Journal of human genetics 50, 99-105. PMID: 15682271

3. Morita, M. et al. (2006) Biological & pharmaceutical bulletin 29, 1836-42. PMID: 16946495

4. van Roermund, CW. et al. (2008) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 22, 4201-8. PMID: 18757502

5. van Roermund, CW. et al. (2011) Biochimica et biophysica acta 1811, 148-52. PMID: 21145416

6. Wiesinger, C. et al. (2013) The Journal of biological chemistry 288, 19269-79. PMID: 23671276

7. Okamoto, T. et al. (2018) Biochemical and biophysical research communications 496, 1122-1127. PMID: 29397936

8. Kawaguchi, K. et al. (2021) Scientific reports 11, 2192. PMID: 33500543

Note

For research use only

图片

参考文献

产品说明书

Anti-ABCD1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ABCD1 Polyclonal Antibody (HA690014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ABCD1 Polyclonal Antibody (HA690014)

概述

图片

参考文献

产品说明书

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