Anti-Human HTR2B Polyclonal Antibody (HA694014)

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概述
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产品说明书

概述

货号

HA694014

品牌

abinScience

描述

Anti-Human HTR2B Polyclonal Antibody (HA694014) is a rabbit polyclonal antibody detecting 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human HTR2B (Leu239-Val325).

靶标

5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; Serotonin receptor 2B; HTR2B

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P41595

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

5-hydroxytryptamine receptor 2B (HTR2B) is a ~54 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways.

1. Cussac, D. et al. (2008) European journal of pharmacology 594, 32-8. PMID: 18703043

2. Wang, C. et al. (2013) Science (New York, N.Y.) 340, 610-4. PMID: 23519210

3. Choi, DS. et al. (1994) FEBS letters 352, 393-9. PMID: 7926008

4. Kursar, JD. et al. (1994) Molecular pharmacology 46, 227-34. PMID: 8078486

5. Schmuck, K. et al. (1994) FEBS letters 342, 85-90. PMID: 8143856

6. Ullmer, C. et al. (1996) British journal of pharmacology 117, 1081-8. PMID: 8882600

7. Schaerlinger, B. et al. (2003) British journal of pharmacology 140, 277-84. PMID: 12970106

8. Wacker, D. et al. (2013) Science (New York, N.Y.) 340, 615-9. PMID: 23519215

10. Wacker, D. et al. (2017) Cell 168, 377-389.e12. PMID: 28129538

Note

For research use only

图片

参考文献

产品说明书

Anti-Human HTR2B Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HTR2B Polyclonal Antibody (HA694014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human HTR2B Polyclonal Antibody (HA694014)

概述

图片

参考文献

产品说明书

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