Anti-PSEN2 Polyclonal Antibody (HW821014)

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100ug

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概述

货号

HW821014

品牌

abinScience

描述

Anti-PSEN2 Polyclonal Antibody (HW821014) is a rabbit polyclonal antibody detecting Presenilin-2; PS-2; 3.4.23.-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2 in ELISA, IHC, WB. Suitable for Human, Pig, Bovine, Rat, and Frog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant human PSEN2 (Lys271-Lys361).

靶标

Presenilin-2; PS-2; 3.4.23.-; AD3LP; AD5; E5-1; STM-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit; PSEN2; AD4; PS2; PSNL2; STM2

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P49810, Q0MS45, Q9XT96, O88777, O12977, Q61144

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236

2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302

3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394

4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189

5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978

6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576

7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369

Note

For research use only

图片

参考文献

产品说明书

Anti-PSEN2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PSEN2 Polyclonal Antibody (HW821014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-PSEN2 Polyclonal Antibody (HW821014)

概述

图片

参考文献

产品说明书

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