DNA polymerase delta subunit 2 (POLD2) is a ~51 kDa protein. Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. 1. Zhang, S. et al. (2007) The Journal of biological chemistry 282, 15330-40. PMID: 173176652. Chea, J. et al. (2012) Cell cycle (Georgetown, Tex.) 11, 2885-95. PMID: 228015433. Lee, YS. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 2954-9. PMID: 244499065. Li, H. et al. (2006) The Journal of biological chemistry 281, 14748-55. PMID: 165104486. Meng, X. et al. (2009) Nucleic acids research 37, 647-57. PMID: 1907419610. Costantino, L. et al. (2014) Science (New York, N.Y.) 343, 88-91. PMID: 24310611 | 
