Anti-EMC10 Polyclonal Antibody (HP872014)

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50ug
100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HP872014

品牌

abinScience

描述

Anti-EMC10 Polyclonal Antibody (HP872014) is a rabbit polyclonal antibody detecting ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1; EMC10; C19orf63; INM02; UNQ764/PRO1556 in ELISA, IHC, WB. Suitable for Human, Bovine, Rat, and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human EMC10 (Gly50-Pro190).

靶标

ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1; EMC10; C19orf63; INM02; UNQ764/PRO1556

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q5UCC4, A1A4M2, Q6AYH6, Q3TAS6

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

ER membrane protein complex subunit 10 (EMC10) is a ~27 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors.

1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231

2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151

3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835

4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656

5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176

6. Reboll, MR. et al. (2017) Circulation 136, 1809-1823. PMID: 28931551

Note

For research use only

图片

参考文献

产品说明书

Anti-EMC10 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-EMC10 Polyclonal Antibody (HP872014)

概述

图片

参考文献

产品说明书

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重组蛋白

抗体

试剂盒

实验相关试剂

Anti-EMC10 Polyclonal Antibody (HP872014)

概述

图片

参考文献

产品说明书

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