

| 货号 | HA786014 | ||||||||
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| 品牌 | abinScience | ||||||||
| 描述 |
Anti-GRB14 Polyclonal Antibody (HA786014) is a rabbit polyclonal antibody detecting Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14 in ELISA, IHC, WB. Suitable for Human, Bovine, Mouse, and Rat.
Highlights
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| 种属反应性 | Human | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human GRB14 (Arg105-Leu540). | ||||||||
| 靶标 | Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14 | ||||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q14449, Q5ICW4, Q9JLM9, O88900 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Growth factor receptor-bound protein 14 (GRB14) is a ~60 kDa protein. Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. | ||||||||
| Note | For research use only |

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