| 背景 | Transforming growth factor beta receptor type 3 (TGFBR3) is a ~93 kDa protein. Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. 1. Chen, W. et al. (2003) Science (New York, N.Y.) 301, 1394-7. PMID: 129583652. Mythreye, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 8221-6. PMID: 194168573. Kirkbride, KC. et al. (2008) The Journal of biological chemistry 283, 7628-37. PMID: 181846614. Lee, NY. et al. (2009) Molecular biology of the cell 20, 4362-70. PMID: 19726563 |
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