| 背景 | Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4) is a ~95 kDa protein. Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. 1. Yang, T. et al. (2001) The Journal of biological chemistry 276, 39569-76. PMID: 115145442. Yang, TT. et al. (2002) Molecular and cellular biology 22, 3892-904. PMID: 119975223. Cho, YY. et al. (2007) The Journal of biological chemistry 282, 8380-92. PMID: 172132025. Qin, X. et al. (2008) Cellular and molecular life sciences : CMLS 65, 2752-62. PMID: 186682016. Mei, Z. et al. (2015) Neurochemical research 40, 829-36. PMID: 256633018. Yang, TT. et al. (2008) Molecular and cellular biology 28, 3489-501. PMID: 18347059 |
|---|
