Anti-Human CMPK2 Polyclonal Antibody (HA833014)

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规格：

50ug
100ug

数量：

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概述
图片
参考文献
产品说明书

概述

货号

HA833014

品牌

abinScience

描述

Anti-Human CMPK2 Polyclonal Antibody (HA833014) is a rabbit polyclonal antibody detecting mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human CMPK2 (Leu99-Pro449).

靶标

UMP-CMP kinase 2, mitochondrial; 2.7.4.14; Nucleoside-diphosphate kinase; 2.7.4.6; CMPK2

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q5EBM0

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

UMP-CMP kinase 2, mitochondrial (CMPK2) is a ~49 kDa protein. Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities. Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor.

1. Xu, Y. et al. (2008) The Journal of biological chemistry 283, 1563-1571. PMID: 17999954

2. El-Diwany, R. et al. (2018) Science advances 4, eaat0843. PMID: 30083606

3. Zhu, M. et al. (2023) PLoS biology 21, e3002039. PMID: 36930652

4. Pawlak, JB. et al. (2023) PLoS pathogens 19, e1011286. PMID: 37075076

Note

For research use only

图片

Western blot

Western blot analysis was performed using anti-CMPK2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate

参考文献

产品说明书

Anti-Human CMPK2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CMPK2 Polyclonal Antibody (HA833014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CMPK2 Polyclonal Antibody (HA833014)

概述

图片

参考文献

产品说明书

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