

| 货号 | HA837014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 品牌 | abinScience | ||||||||
| 描述 |
Anti-OTUD3 Polyclonal Antibody (HA837014) is a rabbit polyclonal antibody detecting OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 种属反应性 | Human, Mouse | ||||||||
| 应用 | ELISA, IHC, WB | ||||||||
| 宿主 | Rabbit | ||||||||
| 克隆类型 | Polyclonal | ||||||||
| 同种型 | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human OTUD3 (Gly46-Lys220). | ||||||||
| 靶标 | OTU domain-containing protein 3; 3.4.19.12; OTUD3; KIAA0459 | ||||||||
| 内毒素水平 | Please contact with the lab for this information. | ||||||||
| 纯化方式 | Purified by antigen affinity column. | ||||||||
| Accession号 | Q5T2D3, B1AZ99 | ||||||||
| 状态 | Liquid | ||||||||
| 保存溶液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| 产品使用信息 |
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| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | OTU domain-containing protein 3 (OTUD3) is a ~45 kDa protein. Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains. Important regulator of energy metabolism. Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation. In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation. 1. Mevissen, TE. et al. (2013) Cell 154, 169-84. PMID: 23827681 2. Garshott, DM. et al. (2020) eLife 9. PMID: 32011234 3. Zhou, N. et al. (2022) Cell metabolism 34, 1023-1041.e8. PMID: 35675826 | ||||||||
| Note | For research use only |

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