Anti-ATP11A Polyclonal Antibody (HB310014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB310014

品牌

abinScience

描述

Anti-ATP11A Polyclonal Antibody (HB310014) is a rabbit polyclonal antibody detecting Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human ATP11A (Asp387-Lys860).

靶标

Phospholipid-transporting ATPase IH; 7.6.2.1; ATPase IS; ATPase class VI type 11A; P4-ATPase flippase complex alpha subunit ATP11A; ATP11A; ATPIH; ATPIS; KIAA1021

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P98196, P98197

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Phospholipid-transporting ATPase IH (ATP11A) is a ~129 kDa protein. Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Does not show flippase activity toward phosphatidylcholine (PC). Contributes to the maintenance of membrane lipid asymmetry with a specific role in morphogenesis of muscle cells. In myoblasts, mediates PS enrichment at the inner leaflet of plasma membrane, triggering PIEZO1-dependent Ca2+ influx and Rho GTPases signal transduction, subsequently leading to the assembly of cortical actomyosin fibers and myotube formation. May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.

1. Takatsu, H. et al. (2014) The Journal of biological chemistry 289, 33543-56. PMID: 25315773

2. Naito, T. et al. (2015) The Journal of biological chemistry 290, 15004-17. PMID: 25947375

3. Segawa, K. et al. (2016) The Journal of biological chemistry 291, 762-72. PMID: 26567335

4. Tsuchiya, M. et al. (2018) Nature communications 9, 2049. PMID: 29799007

5. Wang, J. et al. (2018) Scientific reports 8, 10795. PMID: 30018401

6. Chepurwar, S. et al. (2023) Human molecular genetics 32, 1083-1089. PMID: 36300302

7. Segawa, K. et al. (2021) The Journal of clinical investigation 131. PMID: 34403372

Note

For research use only

图片

参考文献

产品说明书

Anti-ATP11A Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ATP11A Polyclonal Antibody (HB310014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ATP11A Polyclonal Antibody (HB310014)

概述

图片

参考文献

产品说明书

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