Anti-WDR82 Polyclonal Antibody (HB354014)

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概述
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产品说明书

概述

货号

HB354014

品牌

abinScience

描述

Anti-WDR82 Polyclonal Antibody (HB354014) is a rabbit polyclonal antibody detecting WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047 in ELISA, IHC, WB. Suitable for Human, Mouse, Chicken, Frog, and Zebrafish.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human WDR82 (Met1-Asp313).

靶标

WD repeat-containing protein 82; WDR82; SWD2; TMEM113; WDR82A; UNQ9342/PRO34047

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q6UXN9, Q8BFQ4, Q5ZMV7, Q58E77, Q640J6, Q6NV31

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

WD repeat-containing protein 82 (WDR82) is a ~35 kDa protein. Regulatory component of the SET1/COMPASS complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Together with ZC3H4, but independently of the SET1 complex, part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).

1. Lee, JH. et al. (2008) Molecular and cellular biology 28, 609-18. PMID: 17998332

2. Wu, M. et al. (2008) Molecular and cellular biology 28, 7337-44. PMID: 18838538

3. Lee, JH. et al. (2010) The Journal of biological chemistry 285, 24466-76. PMID: 20516061

4. Wang, Z. et al. (2024) Molecular cell 84, 4824-4842.e7. PMID: 39603240

5. Kelley, JR. et al. (2024) Molecular cell 84, 4843-4861.e8. PMID: 39603239

6. Austenaa, LMI. et al. (2021) Nature structural & molecular biology 28, 337-346. PMID: 33767452

7. Estell, C. et al. (2021) eLife 10. PMID: 33913806

Note

For research use only

图片

参考文献

产品说明书

Anti-WDR82 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-WDR82 Polyclonal Antibody (HB354014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-WDR82 Polyclonal Antibody (HB354014)

概述

图片

参考文献

产品说明书

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