Anti-Human SLC4A7 Polyclonal Antibody (HA125024)

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100ug

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概述

货号

HA125024

品牌

abinScience

描述

Anti-Human SLC4A7 Polyclonal Antibody (HA125024) is a rabbit polyclonal antibody detecting Sodium bicarbonate cotransporter 3; Electroneutral Na/HCO(3) cotransporter; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7; SLC4A7; BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant human SLC4A7 (2x(Lys742-Pro819)).

靶标

Sodium bicarbonate cotransporter 3; Electroneutral Na/HCO(3) cotransporter; Sodium bicarbonate cotransporter 2; Sodium bicarbonate cotransporter 2b; Bicarbonate transporter; Solute carrier family 4 member 7; SLC4A7; BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9Y6M7

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Sodium bicarbonate cotransporter 3 (SLC4A7) is a ~136 kDa protein. Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells. Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells.

1. Pushkin, A. et al. (1999) The Journal of biological chemistry 274, 16569-75. PMID: 10347222

2. Park, M. et al. (2002) The Journal of biological chemistry 277, 50503-9. PMID: 12403779

3. Loiselle, FB. et al. (2003) Molecular membrane biology 20, 307-17. PMID: 14578046

4. Loiselle, FB. et al. (2004) American journal of physiology. Cell physiology 286, C1423-33. PMID: 14736710

5. Sedlyarov, V. et al. (2018) Cell host & microbe 23, 766-774.e5. PMID: 29779931

6. Ali, ES. et al. (2022) Molecular cell 82, 3284-3298.e7. PMID: 35772404

Note

For research use only

图片

参考文献

产品说明书

Anti-Human SLC4A7 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC4A7 Polyclonal Antibody (HA125024)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human SLC4A7 Polyclonal Antibody (HA125024)

概述

图片

参考文献

产品说明书

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