| 背景 | Large neutral amino acids transporter small subunit 1 (SLC7A5) is a ~55 kDa protein. The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine. The heterodimer with SLC3A2 mediates the uptake of L-DOPA. Functions as an amino acid exchanger. May play a role in the transport of L-DOPA across the blood-brain barrier. May act as the major transporter of tyrosine in fibroblasts (Probable). 1. Prasad, PD. et al. (1999) Biochemical and biophysical research communications 255, 283-8. PMID: 100497002. Rossier, G. et al. (1999) The Journal of biological chemistry 274, 34948-54. PMID: 105749703. Yanagida, O. et al. (2001) Biochimica et biophysica acta 1514, 291-302. PMID: 115570284. Friesema, EC. et al. (2001) Endocrinology 142, 4339-48. PMID: 115646945. Simmons-Willis, TA. et al. (2002) The Biochemical journal 367, 239-46. PMID: 121174176. Kim, DK. et al. (2002) Biochimica et biophysica acta 1565, 112-21. PMID: 122258597. Li, S. et al. (2005) The Journal of biological chemistry 280, 20102-10. PMID: 157697448. Vumma, R. et al. (2008) Neuroscience letters 434, 56-60. PMID: 182623599. Milkereit, R. et al. (2015) Nature communications 6, 7250. PMID: 25998567 |
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