Anti-Human MC3R Polyclonal Antibody (HC053014)

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100ug

数量：

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概述
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参考文献
产品说明书

概述

货号

HC053014

品牌

abinScience

描述

Anti-Human MC3R Polyclonal Antibody (HC053014) is a rabbit polyclonal antibody detecting Melanocortin receptor 3; MC3-R; MC3R in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human MC3R (Asn2-Gln37&Val101-Asn118&Arg302-Gly323).

靶标

Melanocortin receptor 3; MC3-R; MC3R

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P41968

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Melanocortin receptor 3 (MC3R) is a ~36 kDa protein. G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production.

1. Feng, W. et al. (2023) Cell discovery 9, 81. PMID: 37524700

2. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 8246-50. PMID: 8463333

3. Mencarelli, M. et al. (2008) European journal of human genetics : EJHG 16, 581-6. PMID: 18231126

4. Ollmann, MM. et al. (1997) Science (New York, N.Y.) 278, 135-8. PMID: 9311920

Note

For research use only

图片

参考文献

产品说明书

Anti-Human MC3R Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MC3R Polyclonal Antibody (HC053014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human MC3R Polyclonal Antibody (HC053014)

概述

图片

参考文献

产品说明书

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