Na(+)/dicarboxylate cotransporter 3 (SLC13A3) is a ~66 kDa protein. High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood. Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response. 1. Wang, H. et al. (2000) American journal of physiology. Cell physiology 278, C1019-30. PMID: 107946762. Huang, W. et al. (2000) The Journal of pharmacology and experimental therapeutics 295, 392-403. PMID: 109920063. Burckhardt, BC. et al. (2005) American journal of physiology. Renal physiology 288, F792-9. PMID: 155619734. Stellmer, F. et al. (2007) Journal of molecular medicine (Berlin, Germany) 85, 763-70. PMID: 173568455. Bai, XY. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2409-17. PMID: 174260676. Schorbach, L. et al. (2013) Nephron. Physiology 124, 1-5. PMID: 242471557. Dewulf, JP. et al. (2019) Annals of neurology 85, 385-395. PMID: 306359378. Li, Y. et al. (2025) Nature structural & molecular biology 32, 502-512. PMID: 396229729. Chen, C. et al. (2024) Developmental cell 59, 2807-2817.e8. PMID: 39116875 | 
