Anti-GPS2 Polyclonal Antibody (HB469014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

HB469014

品牌

abinScience

描述

Anti-GPS2 Polyclonal Antibody (HB469014) is a rabbit polyclonal antibody detecting G protein pathway suppressor 2; GPS-2; GPS2 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human GPS2 (Pro2-Lys327).

靶标

G protein pathway suppressor 2; GPS-2; GPS2

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q13227, Q921N8

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

G protein pathway suppressor 2 (GPS2) is a ~36 kDa protein. Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination. In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation. Promotes cholesterol efflux by acting as a transcription coactivator. Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways.

1. Bi, H. et al. (2014) Molecular biology of the cell 25, 2499-508. PMID: 24943844

2. Jakobsson, T. et al. (2009) Molecular cell 34, 510-8. PMID: 19481530

3. Cardamone, MD. et al. (2018) Molecular cell 69, 757-772.e7. PMID: 29499132

4. Cheng, X. et al. (2009) The Journal of biological chemistry 284, 36395-36404. PMID: 19858209

5. Venteclef, N. et al. (2010) Genes & development 24, 381-95. PMID: 20159957

6. Spain, BH. et al. (1996) Molecular and cellular biology 16, 6698-706. PMID: 8943324

7. Huang, XD. et al. (2016) Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 37, 13333-13343. PMID: 27460081

Note

For research use only

图片

参考文献

产品说明书

Anti-GPS2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GPS2 Polyclonal Antibody (HB469014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-GPS2 Polyclonal Antibody (HB469014)

概述

图片

参考文献

产品说明书

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