Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

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100ug

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概述
图片
参考文献
产品说明书

概述

货号

HB533014

品牌

abinScience

描述

Anti-ABRAXAS2 Polyclonal Antibody (HB533014) is a rabbit polyclonal antibody detecting BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157 in ELISA, IHC, WB. Suitable for Human, Mouse, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

种属反应性

Human, Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant human ABRAXAS2 (Met1-Ile158).

靶标

BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B; ABRAXAS2; ABRO1; FAM175B; KIAA0157

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q15018, Q3TCJ1, A6QLR3

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

BRISC complex subunit Abraxas 2 (ABRAXAS2) is a ~46 kDa protein. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression.

1. Cooper, EM. et al. (2009) The EMBO journal 28, 621-31. PMID: 19214193

2. Cooper, EM. et al. (2010) The Journal of biological chemistry 285, 10344-52. PMID: 20032457

3. Feng, L. et al. (2010) The Journal of biological chemistry 285, 30982-8. PMID: 20656690

4. Zheng, H. et al. (2013) Cell reports 5, 180-93. PMID: 24075985

5. Yan, K. et al. (2015) The Journal of cell biology 210, 209-24. PMID: 26195665

6. Zeqiraj, E. et al. (2015) Molecular cell 59, 970-83. PMID: 26344097

7. Zhang, J. et al. (2014) Nature communications 5, 5059. PMID: 25283148

Note

For research use only

图片

参考文献

产品说明书

Anti-ABRAXAS2 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-ABRAXAS2 Polyclonal Antibody (HB533014)

概述

图片

参考文献

产品说明书

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