| 背景 | DNA damage-binding protein 1 (DDB1) is a ~126 kDa protein. Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively. Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. 1. Wertz, IE. et al. (2004) Science (New York, N.Y.) 303, 1371-4. PMID: 147394643. Kulaksiz, G. et al. (2005) Molecular and cellular biology 25, 9784-92. PMID: 162605964. Hu, J. et al. (2006) The Journal of biological chemistry 281, 3753-6. PMID: 164072425. Senga, T. et al. (2006) The Journal of biological chemistry 281, 6246-52. PMID: 164072526. Nishitani, H. et al. (2006) The EMBO journal 25, 1126-36. PMID: 164822157. Lovejoy, CA. et al. (2006) Molecular and cellular biology 26, 7977-90. PMID: 169401748. He, YJ. et al. (2006) Genes & development 20, 2949-54. PMID: 17079684 |
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