Anti-Mouse FPR1 Polyclonal Antibody (MB008014)

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概述
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参考文献
产品说明书

概述

货号

MB008014

品牌

abinScience

描述

Anti-Mouse FPR1 Polyclonal Antibody (MB008014) is a rabbit polyclonal antibody detecting fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor; Fpr1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant mouse FPR1 (Asp2-Val35&Ser92-Phe108&Arg171-Arg216&Gln278-Ile296).

靶标

fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor; Fpr1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P33766

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

N-formyl peptide receptor 1 (FPR1) is a ~40 kDa protein. Pattern recognition G-protein coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis. Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx.

1. Southgate, EL. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1429-37. PMID: 18606697

2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714

3. Gao, JL. et al. (1993) The Journal of biological chemistry 268, 25395-401. PMID: 8244972

4. Gao, JL. et al. (1999) The Journal of experimental medicine 189, 657-62. PMID: 9989980

5. McDonald, B. et al. (2010) Science (New York, N.Y.) 330, 362-6. PMID: 20947763

Note

For research use only

图片

参考文献

产品说明书

Anti-Mouse FPR1 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse FPR1 Polyclonal Antibody (MB008014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse FPR1 Polyclonal Antibody (MB008014)

概述

图片

参考文献

产品说明书

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