Anti-Apelin/APLN Polyclonal Antibody (MV404014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

MV404014

品牌

abinScience

描述

Anti-Apelin/APLN Polyclonal Antibody (MV404014) is a rabbit polyclonal antibody detecting Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel in ELISA, IHC, WB. Suitable for Rat and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse, Rat

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant mouse Apelin/APLN (Val23-Phe77).

靶标

Apelin; APJ endogenous ligand; Apelin-36; Apelin-31; Apelin-28; Apelin-13; Apln; Apel

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

Q9R0R3, Q9R0R4

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Apelin (APLN) is a ~8 kDa protein. Peptide hormone that functions as endogenous ligand for the G-protein-coupled apelin receptor (APLNR/APJ), that plays a role in cadiovascular homeostasis. Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR. Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs. On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor. Apelin blunts cardiac hypertrophic induction from APLNR on response to pathological stimuli, but also induces myocardial hypertrophy under normal conditions.

1. Kawamata, Y. et al. (2001) Biochimica et biophysica acta 1538, 162-71. PMID: 11336787

2. Reaux, A. et al. (2001) Journal of neurochemistry 77, 1085-96. PMID: 11359874

3. Perjés, Á. et al. (2016) Basic research in cardiology 111, 2. PMID: 26611206

4. Lee, DK. et al. (2000) Journal of neurochemistry 74, 34-41. PMID: 10617103

Note

For research use only

图片

参考文献

产品说明书

Anti-Apelin/APLN Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Apelin/APLN Polyclonal Antibody (MV404014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Apelin/APLN Polyclonal Antibody (MV404014)

概述

图片

参考文献

产品说明书

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