Anti-Mouse CCR8 Polyclonal Antibody (MW444014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

MW444014

品牌

abinScience

描述

Anti-Mouse CD198/CCR8 Polyclonal Antibody (MW444014) is a rabbit polyclonal antibody detecting C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Mouse

应用

ELISA, IHC, WB

宿主

Rabbit

同种型

IgG

克隆类型

Polyclonal

免疫原

E. coli - derived recombinant mouse CD198/CCR8 (Asp2-Met33&Asn92-Lys105&Tyr170-Ile200&His262-Leu278).

靶标

C-C chemokine receptor type 8; C-C CKR-8; CC-CKR-8; CCR-8; CDw198; Ccr8; Cmkbr8; Ter1

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P56484

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production.

1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461

2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588

3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532

Note

For research use only

图片

参考文献

产品说明书

Anti-Mouse CCR8 Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse CCR8 Polyclonal Antibody (MW444014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse CCR8 Polyclonal Antibody (MW444014)

概述

图片

参考文献

产品说明书

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