Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

价格:

规格：

50ug
100ug
1mg

数量：

一键复制产品信息

概述
图片
参考文献
产品说明书

HY443043

abinScience

种属反应性

Human

ELISA, FCM, Functional

IgG1, kappa

U.Penn. patent anti-PF4

Platelet factor 4, PF-4, C-X-C motif chemokine 4, Iroplact, Oncostatin-A, Platelet factor 4 short form, Endothelial cell growth inhibitor, PF4, CXCL4, SCYB4

内毒素水平

Please contact with the lab for this information.

>95% as determined by SDS-PAGE.

Protein A/G purified from cell culture supernatant.

Accession号

P02776

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Platelet factor 4 (CXCL4/PF) is a ~10 kDa protein. Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence.

1. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254

2. Lecomte-Raclet, L. et al. (1998) Blood 91, 2772-80. PMID: 9531587

3. Mueller, A. et al. (2008) Journal of leukocyte biology 83, 875-82. PMID: 18174362

4. Van Raemdonck, K. et al. (2014) Angiogenesis 17, 631-40. PMID: 24469069

5. Yang, C. et al. (2022) Nature communications 13, 3426. PMID: 35701499

6. Affandi, AJ. et al. (2022) Cell reports 38, 110189. PMID: 34986347

7. Dudek, AZ. et al. (1997) The Journal of biological chemistry 272, 31785-92. PMID: 9395524

For research use only

Isotype Control

Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

SDS-PAGE

SDS-PAGE for Anti-Human CXCL4/PF4 Antibody (U.Penn. patent anti-PF4)

产品说明书

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CXCL4/PF4 Recombinant Antibody (U.Penn. patent anti-PF4) (HY443043)

概述

图片

参考文献

产品说明书

相关产品推荐

获取报价