Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

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100ug

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概述
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参考文献
产品说明书

概述

货号

VK044014

品牌

abinScience

描述

Anti-HTLV-1 Tax Polyclonal Antibody (VK044014) is a rabbit polyclonal antibody detecting Protein Tax-1 in ELISA, IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

种属反应性

Human T-cell leukemia virus 1 (HTLV-1)

应用

ELISA, IHC, WB

宿主

Rabbit

克隆类型

Polyclonal

同种型

IgG

免疫原

E. coli - derived recombinant HTLV-1 Tax (Gly26-Pro224).

靶标

Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1, Tax

内毒素水平

Please contact with the lab for this information.

纯化方式

Purified by antigen affinity column.

Accession号

P03409

状态

Liquid

保存溶液

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

产品使用信息

应用方法	稀释比例
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Protein Tax-1 is a ~39 kDa protein. Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B.

1. Kusano, S. et al. (2012) Virology 432, 343-52. PMID: 22789739

2. Tie, F. et al. (1996) Journal of virology 70, 8368-74. PMID: 8970957

3. Groussaud, D. et al. (2017) PLoS pathogens 13, e1006518. PMID: 28742148

4. Wang, C. et al. (2016) PLoS pathogens 12, e1005584. PMID: 27082114

5. Shibata, Y. et al. (2017) PLoS pathogens 13, e1006162. PMID: 28103322

Note

For research use only

图片

参考文献

产品说明书

Anti-HTLV-1 Tax Polyclonal Antibody.pdf

公式

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

质量

浓度

体积

分子量 *

g/mol

公式

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

母液

C₁ (起始浓度)

V₁ (起始体积)

工作液

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

概述

图片

参考文献

产品说明书

相关产品推荐

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