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Anti-AAV-8 VP1 Recombinant Antibody (SAA2447) (VK004013)

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  • 1mg
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概述
货号VK004013
品牌abinScience
描述
Anti-AAV8 VP1/Capsid protein VP1 Recombinant Antibody (SAA2447) (VK004013) is a human monoclonal antibody detecting VP1 in ELISA, Neutralization, Dot Blot. Suitable for Adeno-associated virus 8 (AAV8).
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Adeno-associated virus 8 (AAV8)
应用ELISA, Neutralization, Dot Blot
宿主Human
克隆类型Monoclonal
同种型IgG1, kappa
克隆号SAA2447
靶标VP1, Capsid protein
内毒素水平< 10 EU/mg as determined by LAL method.
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号AAN03857.1
状态Liquid
保存溶液 0.01M PBS pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Capsid protein VP1 is a ~81 kDa protein. Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s).

NoteFor research use only
图片

  • SDS-PAGE

    SDS-PAGE for Anti-AAV8 VP1/Capsid protein VP1 Antibody (SAA2447)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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