| 靶标 | CD224, EC:2.3.2.2, EC:3.4.19.13, EC:3.4.19.14, GGT, GGT 1, GGT1, Gamma-glutamyltransferase 1, Gamma-glutamyltranspeptidase 1, Glutathione hydrolase 1 heavy chain, Glutathione hydrolase 1 light chain, Glutathione hydrolase 1 proenzyme, Leukotriene-C4 hydrolase |
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| 背景 | Glutathione hydrolase 1 proenzyme is a ~61 kDa protein. Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4. 1. Castonguay, R. et al. (2007) Biochemistry 46, 12253-62. PMID: 179246582. Wickham, S. et al. (2011) Analytical biochemistry 414, 208-14. PMID: 214473183. Dalli, J. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 12232-12237. PMID: 277910094. Ikeda, Y. et al. (1995) The Journal of biological chemistry 270, 22223-8. PMID: 76732005. Ikeda, Y. et al. (1995) The Journal of biological chemistry 270, 12471-5. PMID: 77594906. Ikeda, Y. et al. (1993) The Journal of biological chemistry 268, 3980-5. PMID: 80950457. Ikeda, Y. et al. (1996) Journal of biochemistry 119, 1166-70. PMID: 8827453 |
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