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Anti-Human PSEN2 Monoclonal Antibody (1A529) (HW821015)

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概述
货号HW821015
品牌abinScience
描述
Anti-Human PSEN2 Monoclonal Antibody (1A529) [1A529] (HW821015) is a mouse monoclonal antibody detecting PSEN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
同种型IgG
克隆号1A529
克隆类型Monoclonal
免疫原E. coli - derived recombinant human PSEN2 (Lys271-Lys361).
靶标Presenilin-2, PS-2, EC:3.4.23.-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P49810
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Presenilin-2 (PSEN2) is a ~50 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Selectively cleaves late endosomal/lysosomal localized substrates and generates the prominent pool of intracellular amyloid beta that contains longer amyloid beta. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.

1. Steiner, H. et al. (1999) The Journal of biological chemistry 274, 28669-73. PMID: 10497236
2. Kimberly, WT. et al. (2000) The Journal of biological chemistry 275, 3173-8. PMID: 10652302
3. Kumar-Singh, S. et al. (2006) Human mutation 27, 686-95. PMID: 16752394
4. Sannerud, R. et al. (2016) Cell 166, 193-208. PMID: 27293189
5. Guo, X. et al. (2022) Nature communications 13, 6299. PMID: 36272978
6. Tu, H. et al. (2006) Cell 126, 981-93. PMID: 16959576
7. Zampese, E. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2777-82. PMID: 21285369
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human PSEN2 Monoclonal Antibody (1A529)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human PSEN2 Monoclonal Antibody (1A529)

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