| 靶标 | Phosphatidylinositol 345-trisphosphate 5-phosphatase 1, EC:3.1.3.86, Inositol polyphosphate-5-phosphatase D, EC:3.1.3.56, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, Phosphatidylinositol 45-bisphosphate 5-phosphatase, EC:3.1.3.36, SH2 domain-containing inositol 5'-phosphatase 1, SH2 domain-containing inositol phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D |
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| 背景 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 107648182. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 87233483. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 87691255. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172 |
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