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Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) (HC152015)

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概述
货号HC152015
品牌abinScience
描述
Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571) [1A571] (HC152015) is a mouse monoclonal antibody detecting ATRX in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A571
免疫原E. coli - derived recombinant human ATRX/RAD54L (Thr1534-Asp1916).
靶标Transcriptional regulator ATRX, EC:3.6.4.12, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX, ATRX
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P46100
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Transcriptional regulator ATRX (RAD54L) is a ~282 kDa protein. Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes.

1. Episkopou, H. et al. (2014) Nucleic acids research 42, 4391-405. PMID: 24500201
2. Valle-García, D. et al. (2016) Epigenetics 11, 398-414. PMID: 27029610
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human ATRX/RAD54L Monoclonal Antibody (1A571)

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