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Anti-Human CIITA Monoclonal Antibody (1A619) (HC153025)

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概述
货号HC153025
品牌abinScience
描述
Anti-Human CIITA Monoclonal Antibody (1A619) [1A619] (HC153025) is a mouse monoclonal antibody detecting CIITA in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A619
免疫原E. coli - derived recombinant human CIITA (Arg886-Arg1130).
靶标MHC class II transactivator, CIITA, EC:2.3.1.-, EC:2.7.11.1, CIITA
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P33076
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

MHC class II transactivator (CIITA) is a ~123 kDa protein. Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes.

1. Al-Kandari, W. et al. (2007) Molecular immunology 44, 311-21. PMID: 16600381
2. Al-Kandari, W. et al. (2007) Journal of molecular biology 369, 1175-87. PMID: 17493635
3. Riley, JL. et al. (1995) Immunity 2, 533-43. PMID: 7749984
4. Steimle, V. et al. (1993) Cell 75, 135-46. PMID: 8402893
5. Maassen, F. et al. (2025) eLife 14. PMID: 40608405
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human CIITA Monoclonal Antibody (1A619)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CIITA Monoclonal Antibody (1A619)

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