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Anti-Human CD35 Monoclonal Antibody (1A627) (HB625015)

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概述
货号HB625015
品牌abinScience
描述
Anti-Human CD35/CR1 Monoclonal Antibody (1A627) [1A627] (HB625015) is a mouse monoclonal antibody detecting CD35 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Recombinant — Superior batch-to-batch reproducibility with defined sequences.
  • ●Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Mouse
克隆类型Monoclonal
同种型IgG
克隆号1A627
免疫原E. coli - derived recombinant human CD35/CR1 (Asp1740-Asp1971).
靶标Complement receptor type 1, C3b/C4b receptor, CD35, CR1
纯化方式Protein A/G purified from cell culture supernatant.
Accession号P17927
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells.

1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069
2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794
3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757
4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
NoteFor research use only.
图片

  • SDS-PAGE

    SDS-PAGE for Anti-Human CD35/CR1 Monoclonal Antibody (1A627)

参考文献
产品说明书
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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Anti-Human CD35 Monoclonal Antibody (1A627)

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