

| 货号 | HF717025 |
|---|---|
| 品牌 | abinScience |
| 描述 |
Anti-Human SH2D1A Monoclonal Antibody (1A651) [1A651] (HF717025) is a mouse monoclonal antibody detecting SH2D1A in ELISA, IHC, WB. Suitable for Human.
Highlights
|
| 种属反应性 | Human |
| 应用 | ELISA, IHC, WB |
| 宿主 | Mouse |
| 克隆类型 | Monoclonal |
| 同种型 | IgG |
| 克隆号 | 1A651 |
| 免疫原 | E. coli - derived recombinant human SH2D1A (Asp2-Pro97). |
| 靶标 | SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | O60880 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | SH2 domain-containing protein 1A (SH2D1A) is a ~14 kDa protein. Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. 1. Howie, D. et al. (2002) Blood 99, 957-65. PMID: 11806999 2. Li, C. et al. (2003) The Journal of biological chemistry 278, 3852-9. PMID: 12458214 |
| Note | For research use only. |

SDS-PAGE for Anti-Human SH2D1A Monoclonal Antibody (1A651)



24小时产品查询

扫一扫关注我们

专属渠道经理