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Anti-Human CMTM6 Recombinant Nanobody (SAA2685) (HD496013)

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概述
货号HD496013
品牌abinScience
描述
Anti-Human CMTM6 Nanobody (SAA2685) [SAA2685] (HD496013) is a alpaca monoclonal antibody detecting CMTM6 in ELISA. Suitable for Human.
种属反应性Human
应用ELISA
宿主Alpaca
克隆类型Monoclonal
同种型VHH-8His
克隆号SAA2685
靶标CKLF-like MARVEL transmembrane domain-containing protein 6, CKLFSF6, CMTM6, Chemokine-like factor superfamily member 6
内毒素水平<10 EU/mg
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
Accession号Q9NX76
状态Liquid
保存溶液 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is a ~20 kDa protein. Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

NoteFor research use only
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公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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