Anti-Human CLDN18 Recombinant Antibody (43-14A) (HX126023)

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货号	HX126023
品牌	abinScience
种属反应性	Human
应用	IHC-P
宿主	Mouse
克隆类型	Monoclonal
同种型	IgG2b
克隆号	43-14A
靶标	CLDN18, Claudin-18
内毒素水平	< 10 EU/mg
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
Accession号	P56856
状态	Liquid
保存溶液	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Claudin-18 (CLDN18) is a ~27 kDa protein. Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling. Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier. Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription. Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency. Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways.
Note	For research use only

产品说明书

Anti-Human CLDN18 Recombinant Antibody (43-14A).pdf

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Anti-Human CLDN18 Recombinant Antibody (43-14A) (HX126023)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Human CLDN18 Recombinant Antibody (43-14A) (HX126023)

概述

图片

参考文献

产品说明书

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