Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

价格:

规格：

50ug
100ug
1mg

数量：

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概述
图片
参考文献
产品说明书

MV466013

abinScience

种属反应性

Mouse

ELISA, FACS, Functional assay, Research in vivo

IgG1, kappa

G23-8

IL-23 subunit alpha, IL-23-A, IL-23p19, Il23a, Interleukin-23 subunit alpha, Interleukin-23 subunit p19

内毒素水平

<1 EU/mg

>95% as determined by SDS-PAGE.

pH 7.4 Dilution Buffer

Protein A/G purified from cell culture supernatant.

Accession号

Q9EQ14

Liquid

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

产品使用信息

应用方法	稀释比例
ELISA	1:2000-1:20000

稳定性和存储

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Interleukin-23 subunit alpha (IL-23 p19) is a ~22 kDa protein. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

1. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383

2. Wiekowski, MT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 7563-70. PMID: 11390512

3. Yen, D. et al. (2006) The Journal of clinical investigation 116, 1310-6. PMID: 16670770

4. Li, X. et al. (2010) Immunology letters 127, 100-7. PMID: 19900478

5. Happel, KI. et al. (2005) The Journal of experimental medicine 202, 761-9. PMID: 16157683

6. Mangan, PR. et al. (2006) Nature 441, 231-4. PMID: 16648837

For research use only

产品说明书

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8).pdf

质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)

填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。

分子量 *

g/mol

C₁ × V₁ = C₂ × V₂

填写 4 项中的任意 3 项，自动计算未知值。

C₁ (起始浓度)

V₁ (起始体积)

C₂ (终浓度)

V₂ (终体积)

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

概述

图片

参考文献

产品说明书

相关产品推荐

重组蛋白

抗体

试剂盒

实验相关试剂

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

概述

图片

参考文献

产品说明书

相关产品推荐

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