

| 货号 | ARO-A13331 |
|---|---|
| 品牌 | ProteoGenix |
| 描述 |
InVivoMAb Anti-Rotavirus A/RV-A Outer capsid glycoprotein VP7 (Iv0011) (ARO-A13331) Purity: >95% as determined by SDS-PAGE..
Highlights
|
| 种属反应性 | Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]) (RV-A) |
| 应用 | ELISA, Neutralization |
| 宿主 | Mouse |
| 同种型 | IgG2a, kappa |
| 克隆号 | Iv0011 |
| 克隆类型 | Monoclonal |
| 靶标 | Outer capsid glycoprotein VP7 |
| 内毒素水平 | Please contact with the lab for this information. |
| 纯度 | >95% as determined by SDS-PAGE. |
| 相关产品 | pH 7.4 Dilution Buffer |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| Accession号 | P12476 |
| 状态 | Liquid |
| 保存溶液 | 0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 稳定性和存储 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Outer capsid glycoprotein VP7 is a ~37 kDa protein. Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca(2+) concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7. 1. Aoki, ST. et al. (2011) Journal of virology 85, 10509-17. PMID: 21849465 2. Abdelhakim, AH. et al. (2014) PLoS pathogens 10, e1004355. PMID: 25211455 3. Settembre, EC. et al. (2011) The EMBO journal 30, 408-16. PMID: 21157433 |
| Note | For research use only. Not suitable for clinical or therapeutic use. |

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