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Anti-Human CELF1 Polyclonal Antibody (ARO-A12952)

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概述
货号ARO-A12952
品牌ProteoGenix
描述
Anti-Human CELF1 Polyclonal Antibody (ARO-A12952) is a rabbit polyclonal antibody detecting CELF-1, CUGBP1, CUGBP Elav-like family member 1, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, EDEN-BP homolog, CELF1, RNA-binding protein BRUNOL-2, 50 kDa nuclear polyadenylated RNA-binding protein, CUG triplet repeat RNA-binding protein 1, BRUNOL2, CUGBP, NAB50, CUG-BP- and ETR-3-like factor 1, Bruno-like protein 2, CUG-BP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CELF1 (Lys17-Asp187).
靶标CELF-1, CUGBP1, CUGBP Elav-like family member 1, Deadenylation factor CUG-BP, Embryo deadenylation element-binding protein homolog, EDEN-BP homolog, CELF1, RNA-binding protein BRUNOL-2, 50 kDa nuclear polyadenylated RNA-binding protein, CUG triplet repeat RNA-binding protein 1, BRUNOL2, CUGBP, NAB50, CUG-BP- and ETR-3-like factor 1, Bruno-like protein 2, CUG-BP1
纯化方式Purified by antigen affinity column.
Accession号Q92879
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

CUGBP Elav-like family member 1 (CELF1) is a ~52 kDa protein. RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs.

1. Treiber, T. et al. (2017) Molecular cell 66, 270-284.e13. PMID: 28431233
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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