| 背景 | Palmitoyltransferase ZDHHC5 is a ~77 kDa protein. Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates such as CTNND2, CD36, GSDMD, NLRP3, NOD1, NOD2, STAT3 and S1PR1 thus plays a role in various biological processes including cell adhesion, inflammation, fatty acid uptake, bacterial sensing or cardiac functions. Plays an important role in the regulation of synapse efficacy by mediating palmitoylation of delta-catenin/CTNND2, thereby increasing synaptic delivery and surface stabilization of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). Under basal conditions, remains at the synaptic membrane through FYN-mediated phosphorylation that prevents association with endocytic proteins. Neuronal activity enhances the internalization and trafficking of DHHC5 from spines to dendritic shafts where it palmitoylates delta-catenin/CTNND2. Regulates cell adhesion at the plasma membrane by palmitoylating GOLGA7B and DSG2. 1. Kokkola, T. et al. (2011) FEBS letters 585, 2665-70. PMID: 218204372. Badawy, SMM. et al. (2017) Scientific reports 7, 16552. PMID: 291854524. Lu, Y. et al. (2019) Science (New York, N.Y.) 366, 460-467. PMID: 316491955. Dixon, CL. et al. (2021) Journal of lipid research 62, 100097. PMID: 342934016. Zheng, S. et al. (2023) Molecular cell 83, 4570-4585.e7. PMID: 380920007. Balasubramanian, A. et al. (2024) Science immunology 9, eadn1452. PMID: 385301589. Brigidi, GS. et al. (2015) Nature communications 6, 8200. PMID: 2633472310. Hao, JW. et al. (2020) Nature communications 11, 4765. PMID: 32958780 |
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