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Anti-Human CNOT7 Polyclonal Antibody (ARO-A12913)

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概述
货号ARO-A12913
品牌ProteoGenix
描述
Anti-Human CNOT7 Polyclonal Antibody (ARO-A12913) is a rabbit polyclonal antibody detecting CNOT7, BTG1-binding factor 1, CAF-1, CAF1, Caf1a, CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CNOT7 (Arg11-Ser285).
靶标CNOT7, BTG1-binding factor 1, CAF-1, CAF1, Caf1a, CCR4-NOT transcription complex subunit 7, CCR4-associated factor 1
纯化方式Purified by antigen affinity column.
Accession号Q9UIV1
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

CCR4-NOT transcription complex subunit 7 (CNOT7) is a ~32 kDa protein. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression.

1. Horiuchi, M. et al. (2009) The Journal of biological chemistry 284, 13244-55. PMID: 19276069
2. Cooke, A. et al. (2010) The Journal of biological chemistry 285, 28506-13. PMID: 20634287
3. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 31439799
4. Aslam, A. et al. (2009) Molecular biology of the cell 20, 3840-50. PMID: 19605561
5. Piao, X. et al. (2010) Molecular and cellular biology 30, 1486-94. PMID: 20065043
6. Doidge, R. et al. (2012) PloS one 7, e51331. PMID: 23236473
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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