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Anti-Human CCDC22 Polyclonal Antibody (ARO-A13435)

概述
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概述

货号	ARO-A13435
品牌	ProteoGenix
描述	Anti-Human CCDC22 Polyclonal Antibody (ARO-A13435) is a rabbit polyclonal antibody detecting Coiled-coil domain-containing protein 22, CCDC22, CXorf37 in ELISA, IHC, WB. Suitable for Human. Highlights Affinity Purified — Minimal background and high purity for reliable results. Multi-Application — Validated across multiple applications.
种属反应性	Human
应用	ELISA, IHC, WB
宿主	Rabbit
克隆类型	Polyclonal
同种型	IgG
免疫原	E. coli - derived recombinant Human CCDC22 (Met1-Arg107).
靶标	Coiled-coil domain-containing protein 22, CCDC22, CXorf37
纯化方式	Purified by antigen affinity column.
Accession号	O60826
状态	Liquid
保存溶液	0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	Coiled-coil domain-containing protein 22 (CCDC22) is a ~70 kDa protein. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the Commander complex is composed of composed of the CCC subcomplex and the retriever subcomplex. Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. 1. Healy, MD. et al. (2023) Cell 186, 2219-2237.e29. PMID: 37172566 2. Laulumaa, S. et al. (2024) Nature structural & molecular biology 31, 925-938. PMID: 38459129 3. Starokadomskyy, P. et al. (2013) The Journal of clinical investigation 123, 2244-56. PMID: 23563313 4. Phillips-Krawczak, CA. et al. (2015) Molecular biology of the cell 26, 91-103. PMID: 25355947 5. McNally, KE. et al. (2017) Nature cell biology 19, 1214-1225. PMID: 28892079
Note	For research use only.

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公式

C₁ × V₁ = C₂ × V₂

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母液

C₁ (起始浓度)

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V₁ (起始体积)

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工作液

C₂ (终浓度)

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V₂ (终体积)

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Anti-Human CCDC22 Polyclonal Antibody

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