| 背景 | L-amino-acid oxidase (IL4I1) is a ~70 kDa protein. Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. 2. Mason, JM. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 173, 4561-7. PMID: 153835893. Lasoudris, F. et al. (2011) European journal of immunology 41, 1629-38. PMID: 214691145. Cousin, C. et al. (2015) European journal of immunology 45, 1772-82. PMID: 257787936. Bod, L. et al. (2018) Journal of immunology (Baltimore, Md. : 1950) 200, 1027-1038. PMID: 29288206 |
|---|
