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Anti-Mouse PGLYRP1 Polyclonal Antibody (ARO-A11114)

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概述
货号ARO-A11114
品牌ProteoGenix
描述
Anti-Mouse PGLYRP1 Polyclonal Antibody (ARO-A11114) is a rabbit polyclonal antibody detecting Peptidoglycan recognition protein 1 (Cytokine tag7) (Peptidoglycan recognition protein short) (PGRP-S) in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Mouse
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Mouse PGLYRP1 (Val41-Glu182).
靶标Peptidoglycan recognition protein 1 (Cytokine tag7) (Peptidoglycan recognition protein short) (PGRP-S)
纯化方式Purified by antigen affinity column.
Accession号O88593
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Peptidoglycan recognition protein 1 (PGLYRP1) is a ~20 kDa protein. Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system.

1. Dziarski, R. et al. (2003) Blood 102, 689-97. PMID: 12649138
2. Kiselev, SL. et al. (1998) The Journal of biological chemistry 273, 18633-9. PMID: 9660837
3. Kang, D. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 10078-82. PMID: 9707603
4. Sashchenko, LP. et al. (2004) The Journal of biological chemistry 279, 2117-24. PMID: 14585845
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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