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Anti-Human CDCA7 Polyclonal Antibody (ARO-A11127)

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概述
货号ARO-A11127
品牌ProteoGenix
描述
Anti-Human CDCA7 Polyclonal Antibody (ARO-A11127) is a rabbit polyclonal antibody detecting CDCA7, JPO1, Cell division cycle-associated protein 7, Protein JPO1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human CDCA7 (Thr246-Ala371).
靶标CDCA7, JPO1, Cell division cycle-associated protein 7, Protein JPO1
纯化方式Purified by antigen affinity column.
Accession号Q9BWT1
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Cell division cycle-associated protein 7 (CDCA7) is a ~42 kDa protein. Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator.

1. Prescott, JE. et al. (2001) The Journal of biological chemistry 276, 48276-84. PMID: 11598121
2. Osthus, RC. et al. (2005) Cancer research 65, 5620-7. PMID: 15994934
3. Gill, RM. et al. (2013) Molecular and cellular biology 33, 498-513. PMID: 23166294
4. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408
5. Wassing, IE. et al. (2024) Science advances 10, eadp5753. PMID: 39178260
6. Goto, Y. et al. (2006) Biochimica et biophysica acta 1759, 60-8. PMID: 16580749
NoteFor research use only.
图片
参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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