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Anti-Human TOMM22 Polyclonal Antibody (ARO-A11172)

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概述
货号ARO-A11172
品牌ProteoGenix
描述
Anti-Human TOMM22 Polyclonal Antibody (ARO-A11172) is a rabbit polyclonal antibody detecting 1C9-2, TOM22, Translocase of outer membrane 22 kDa subunit homolog, hTom22, Mitochondrial import receptor subunit TOM22 homolog, TOMM22 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • Affinity Purified — Minimal background and high purity for reliable results.
  • Multi-Application — Validated across multiple applications.
种属反应性Human
应用ELISA, IHC, WB
宿主Rabbit
克隆类型Polyclonal
同种型IgG
免疫原E. coli - derived recombinant Human TOMM22 (Glu42-Ala84).
靶标1C9-2, TOM22, Translocase of outer membrane 22 kDa subunit homolog, hTom22, Mitochondrial import receptor subunit TOM22 homolog, TOMM22
纯化方式Purified by antigen affinity column.
Accession号Q9NS69
状态Liquid
保存溶液 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
稳定性和存储Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景

Mitochondrial import receptor subunit TOM22 homolog (TOMM22) is a ~15 kDa protein. Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.

1. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546
2. Yano, M. et al. (2000) Molecular and cellular biology 20, 7205-13. PMID: 10982837
NoteFor research use only.
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参考文献
公式
质量 (g) = 浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)
填写 质量、浓度、体积中的任意 2 项 + 分子量，自动计算未知值。
质量
=
浓度
×
体积
分子量 *
g/mol
公式
C₁ × V₁ = C₂ × V₂
填写 4 项中的任意 3 项，自动计算未知值。
母液
C₁ (起始浓度)
×
V₁ (起始体积)
=
工作液
C₂ (终浓度)
×
V₂ (终体积)

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